Obesity
Obesity & IVF
*Normal weight women- 10.9% IVF cancellation rate
*Morbidly obese women- 25% cancellation rate
Dokras et al ObGyn 2006n
*Retrospective study looking at 6500 IVF/ICSI cycles
*Obese women had decreased implantation, pregnancy and live birth rates OR decreased 0.98 with each unit increase in BMI
Bellver et al F&S 2007& 2010
Obesity & Miscarriage Rate
Lashen et al:
*matched case control study
*1644 obese and 3288 normal weight women
*Obesity increases miscarriage rate (OR 1.2)
*Obesity increases recurrent sab (OR 3.5)
Lashen et al HR 2004
*Bellver et al 2007/10 – IVF
*No difference in miscarriage rate
Obesity and IVF
*Study to evaluate the impact of third-party surrogate BMI in egg-donor cycles
*IRB approved, retrospective study.
*349 third-party surrogates undergoing IVF with egg donation by a single physician during the period November 1998 – December 2007 (PFCLA)
*Multivariate analysis was performed to adjust for the following potential confounders:
*Number and Quality of Embryos
*Type of Embryo (Frozen vs. Fresh)
*Egg Donor Age
DeUgarte D , DeUgarte C et al
Fertil Steril. 2009 Sep 4.
Obesity and infertility
Lashen et al:
*matched case control study
*1644 obese and 3288 normal weight women
*Obesity increases miscarriage rate (OR 1.2)
*Obesity increases recurrent sab (OR 3.5)
Lashen et al HR 2004
*Bellver et al 2007/10 – IVF
*No difference in miscarriage rate
Obesity and IVF
*Study to evaluate the impact of third-party surrogate BMI in egg-donor cycles
*IRB approved, retrospective study.
*349 third-party surrogates undergoing IVF with egg donation by a single physician during the period November 1998 – December 2007 (PFCLA)
*Multivariate analysis was performed to adjust for the following potential confounders:
*Number and Quality of Embryos
*Type of Embryo (Frozen vs. Fresh)
*Egg Donor Age
DeUgarte D , DeUgarte C et al
Fertil Steril. 2009 Sep 4.
Obesity and infertility
“extreme levels of obesity may negatively influence male reproductive potential”
*483 pts
*↑BMI men had↑ increased estradiol levels and ↓ total testosterone and sex hormone-binding glogulin (SHBG)
strong inverse relation between BMI and inhibin B levels and a lower testosterone:LH ratio among men with a BMI >/=35 kg/m(2).
*Body mass index was unrelated to sperm concentration, motility, or morphology.
*Ejaculate volume decreased steadily with increasing BMI levels.
*Men with BMI >/=35 kg/m(2) had a lower total sperm count (concentration x volume) than normal weight men
*Sperm with high DNA damage were significantly more numerous in obese men than in normal-weight men.
Fertil Steril. 2009 Mar 2- Chavarro et al